Chronotropic, Inotropic, Dromotropic and Coronary Vasodilator Effects of Bisaramil, a New Class I Antiarrhythmic Drug, Assessed Using Canine Isolated, Blood-Perfused Heart Preparations

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Author(s)

Abstract

The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(3), 267-270, 1999-07

    The Japanese Pharmacological Society

References:  10

Codes

  • NII Article ID (NAID)
    10008195458
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4806343
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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