Chronotropic, Inotropic, Dromotropic and Coronary Vasodilator Effects of Bisaramil, a New Class I Antiarrhyihmic Drug, Assessed Using Canine Isolated, Blood-Perfused Heart Preparatios.
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- Haruno Akihiro
- Department of Pharmacology, Yamanashi Medical University
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- Sugiyama Atsushi
- Department of Pharmacology, Yamanashi Medical University
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- Hashimoto Keitaro
- Department of Pharmacology, Yamanashi Medical University
Bibliographic Information
- Other Title
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- Chronotropic,Inotropic,Dromotropic and Coronary Vasodilator Effects of Bisaramil,a New Class I Antiarrhythmic Drug,Assessed Using Canine Isolated,Blood-Perfused Heart Preparations
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Abstract
The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 80 (3), 267-270, 1999
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679261665792
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- NII Article ID
- 10008195458
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXkslKrtLg%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4806343
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- PubMed
- 10461773
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4806343
- https://api.elsevier.com/content/article/PII:S0021519819308522?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819308522?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/80/3/80_3_267/_pdf
- https://search.jamas.or.jp/link/ui/2000023790
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed