Effects of Phenylephrine and Prazosin on Axial Movement of the Rat Incisor and Arterial Blood Pressure

Access this Article

Author(s)

Abstract

We investigated the dose-response effects of phenylephrine and antagonistic effects of prazosin on axial movement of the rat incisor and arterial blood pressure. Phenylephrine caused a temporal extrusive tooth movement and an increase in blood pressure at all doses. With increasing phenylephrine doses, the maximum extrusive tooth movement and maximum increase in blood pressure were enhanced. The maximum extrusive tooth movement and increase in blood pressure induced by phenylephrine were markedly suppressed after pretreatment with prazosin. These results suggested that extrusive tooth movement is closely related to the rise in blood pressure due to stimulation of vascular α<SUB>1</SUB>-receptors.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(3), 271-274, 1999-07

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008195469
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4806347
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
Page Top