Effects of Phenylephrine and Prazosin on Axial Movement of the Rat Incisor and Arterial Blood Pressure.

• Ohyama Nami

  Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University

• Yamaguchi Shizuyo

  Department of Pharmacology, School of Dental Medicine, Tsurumi University

Abstract

We investigated the dose-response effects of phenylephrine and antagonistic effects of prazosin on axial movement of the rat incisor and arterial blood pressure. Phenylephrine caused a temporal extrusive tooth movement and an increase in blood pressure at all doses. With increasing phenylephrine doses, the maximum extrusive tooth movement and maximum increase in blood pressure were enhanced. The maximum extrusive tooth movement and increase in blood pressure induced by phenylephrine were markedly suppressed after pretreatment with prazosin. These results suggested that extrusive tooth movement is closely related to the rise in blood pressure due to stimulation of vascular α₁-receptors.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 80 (3), 271-274, 1999

  The Japanese Pharmacological Society

Keywords

• Phenylephrine
• Prazosin
• Tooth movement

Details

• CRID: 1390282679261664640
• NII Article ID: 10008195469
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.80.271
• COI: 1:CAS:528:DyaK1MXkslKrtLk%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4806347
• PubMed: 10461774
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4806347
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819308534?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819308534?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/80/3/80_3_271/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000025302
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed