Both Wortmannin and Simvastatin Inhibit the Adipogenesis in 3T3-L1 Cells During the Late Phase of Differentiation

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Author(s)

Abstract

As we reported previously, both wortmannin and lovastatin inhibit the differentiation in 3T3-L1 cells when these drugs were applied during the insulin-induced cell differentiation. In the present study, 3T3-L1 cells were treated with wortmannin and simvastatin after the completion of the insulin-stimulation, and differentiation was found to be significantly decreased by these drugs. This suggests intracellular signaling pathways play roles in the differentiation of 3T3-L1 cells even after the completion of the insulin-stimulation and also suggests that not only the early phase (day 0 to day 2) but also the late phase (day 2 to day 4) of differentiation is important for the differentiation of the cells.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(4), 375-378, 1999-08-01

    The Japanese Pharmacological Society

References:  16

Codes

  • NII Article ID (NAID)
    10008195929
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4837050
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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