Monitoring of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats

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Author(s)

Abstract

The <I>Kampo</I> medicine <I>Sho-saiko-to</I> scavenged superoxide anion radicals (O<SUB>2</SUB><SUP>-</SUP>), hydroxyl radicals (·OH) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of <I>Sho-saiko-to</I> in rats. From the response-time profile, kinetic parameters including values for K<SUB>a</SUB> (absorption rate constant), T<SUB>max</SUB> (peak concentration time), T<SUB>1/2</SUB> (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O<SUB>2</SUB><SUP>-</SUP>, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of <I>Sho-saiko-to</I>.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(4), 379-382, 1999-08-01

    The Japanese Pharmacological Society

References:  14

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008195946
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4837059
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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