Antioxidant Action of the Antiarrhythmic Drug Mexiletine in Brain Membranes

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Mexiletine is a class Ib antiarrhythmic drug used in the treatment of ventricular arrhythmias. The Na<SUP>+</SUP> channel blocker mexiletine inhibits calcium influx in cells via decreasing reverse operation of the Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchanger. Thus this drug is shown to protect the CNS white matter against anoxic/ischemic injury. The aim of our study was to investigate if this drug could act as an antioxidant drug as well. The antioxidant action of this drug was studied under different oxidant conditions in vitro, and thiobarbituric acid - reactive substances were measured to follow lipid peroxidation. Mexiletine inhibited iron-ascorbate-H<SUB>2</SUB>O<SUB>2</SUB> - induced lipid peroxidation in brain membranes, liver microsomes and phospholipid liposomes, being most effective in brain membranes. The inhibition was dose- and time-dependent. Mexiletine also inhibited copper-ascorbate-H<SUB>2</SUB>O<SUB>2</SUB> - induced lipid peroxidation but to a lesser extent. It is concluded that mexiletine has a dual effect toward oxidative injury in brain, both by inhibiting Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchanger-dependent Ca<SUP>2+</SUP> influx and by acting as an inhibitor of lipid peroxidation. However, as this drug is effective at millimolar concentrations, it should be considered less active than natural antioxidants that are effective at micromolar concentrations.

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  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(1), 7-11, 1999-09

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008195996
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4867747
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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