Antinociceptive Effect of R-(+)-Hyoscyamine on the Conjunctival Reflex Test in Rabbits
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<I>R</I>-(+)-Hyoscyamine (1 - 10 μg/kg, s.c.) dose-dependently increased the local anesthetic effect of procaine (50 μg/ml) and lidocaine (50 μg/ml) in the conjunctival reflex test in the rabbit. This potentiating effect is completely prevented by the M<SUB>1</SUB> antagonist dicyclomine (10 mg/kg, s.c.). The intensity of <I>R</I>-(+)-hyoscyamine antinociception was comparable to that induced by morphine (2 mg/kg, s.c.) and minaprine (15 mg/kg, s.c.), used as analgesic reference drugs. In the same experimental conditions, the <I>S</I>-(-)-enantiomer of atropine (0.1 - 10 μg/kg, s.c.), was completely ineffective. The present results confirm the ability of <I>R</I>-(+)-hyoscyamine to produce a paradoxical antinociceptive effect mediated by a cholinergic mechanism not only in rodents but also in the rabbit.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 81(1), 34-37, 1999-09
The Japanese Pharmacological Society