Antinociceptive Effect of R-(+)-Hyoscyamine on the Conjunctival Reflex Test in Rabbits.
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- Ghelardini Carla
- Department of Pharmacology, University of Florence, Viale G. Pieraccini
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- Galeotti Nicoletta
- Department of Pharmacology, University of Florence, Viale G. Pieraccini
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- Fantetti Lia
- Department of Pharmacology, University of Florence, Viale G. Pieraccini
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- Gualtieri Fulvio
- Department of Pharmaceutical Sciences, University of Florence, Via G. Capponi
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- Scapecchi Serena
- Department of Pharmaceutical Sciences, University of Florence, Via G. Capponi
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- Bartolini Alessandro
- Department of Pharmacology, University of Florence, Viale G. Pieraccini
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Abstract
R-(+)-Hyoscyamine (1 - 10 μg/kg, s.c.) dose-dependently increased the local anesthetic effect of procaine (50 μg/ml) and lidocaine (50 μg/ml) in the conjunctival reflex test in the rabbit. This potentiating effect is completely prevented by the M1 antagonist dicyclomine (10 mg/kg, s.c.). The intensity of R-(+)-hyoscyamine antinociception was comparable to that induced by morphine (2 mg/kg, s.c.) and minaprine (15 mg/kg, s.c.), used as analgesic reference drugs. In the same experimental conditions, the S-(-)-enantiomer of atropine (0.1 - 10 μg/kg, s.c.), was completely ineffective. The present results confirm the ability of R-(+)-hyoscyamine to produce a paradoxical antinociceptive effect mediated by a cholinergic mechanism not only in rodents but also in the rabbit.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 81 (1), 34-37, 1999
The Japanese Pharmacological Society
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Details
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- CRID
- 1390001204284842880
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- NII Article ID
- 10008196099
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXmt1Cqur4%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4867787
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- PubMed
- 10580368
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed