Mechanism of Structural Remodelling of the Rat Aorta During Long-Term N^G-Nitro-_L-arginine Methyl Ester Treatment

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Author(s)

Abstract

The aim of the present study was to determine whether decreased nitric oxide (NO) synthase production or rather <I>N</I><SUP>G</SUP>-nitro-L-arginine methyl ester (L-NAME)-induced hypertension was responsible for metabolic and structural remodelling of the rat aorta during four-week L-NAME treatment. Three groups of male Wistar rats were investigated: control, treated with 20 mg/kg per day L-NAME (L-NAME<SUB>20</SUB>), and treated with 40 mg/kg per day L-NAME (L-NAME<SUB>40</SUB>). Systolic blood pressure significantly increased in L-NAME<SUB>20</SUB> to 146% and in L-NAME<SUB>40</SUB> to 149% of the control value. NO synthase activity in the aorta significantly decreased in L-NAME<SUB>20</SUB> and L-NAME<SUB>40</SUB> to 86% and 65% of the control values, respectively. Proteosynthesis was significantly elevated in both L-NAME groups, while nuclear DNA concentration was significantly elevated only in the L-NAME<SUB>40</SUB> group. Cyclic GMP concentration significantly decreased in L-NAME<SUB>20</SUB> to 73% and in L-NAME<SUB>40</SUB> to 46% of the control. Cyclic AMP concentration significantly increased in L-NAME<SUB>20</SUB> and L-NAME<SUB>40</SUB> to 128% and 145% of the control value, respectively. The diameter and wall thickness-to-diameter ratio were significantly elevated only in the L-NAME<SUB>40</SUB> group. We conclude that remodelling of the aorta in L-NAME-treated rats was rather associated with NO deficiency than L-NAME-induced hypertension.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(1), 99-106, 1999-09

    The Japanese Pharmacological Society

References:  39

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008196324
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4867917
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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