Diazepam Increases Calcium Sensitivity of the Skinned Cardiac Muscle Fiber in Guinea Pig

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Author(s)

    • Hara Yukio HARA Yukio
    • Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato University
    • NISHINO Takeshi
    • Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato University
    • KONDO Hiroshi
    • Department of Veterinary Pharmacology. School of Veterinary Medicine and Animal Sciences, Kitasato University

Abstract

Influences of diazepam, a benzodiazepine derivative, on the contractile response to calcium in skinned trabecular fibers of guinea pig heart were examined. Diazepam (100 μM) enhanced the contractile response of the skinned fiber to calcium and shifted the concentration-response curve to the left. The pCa<SUB>50</SUB> values were 6.07±0.03 and 6.28±0.03 (P<0.05) in the absence and presence of diazepam, respectively. This result suggests that diazepam increases calcium sensitivity of contractile proteins in heart muscles.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(1), 122-124, 1999-09

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008196402
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4867945
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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