Effects of β-Blockers and Nicardipine on Oxotremorine-Induced Tremor in Common Marmosets

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Author(s)

Abstract

Effects of β-blockers (propranolol, arotinolol and nipradilol) and a Ca<SUP>2+</SUP> channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as “points”, which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. β-Blockers significantly suppressed the tremor. On the other hand, the Ca<SUP>2+</SUP> channel blocker exacerbated the tremor.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(2), 244-246, 1999-10

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008197072
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4886743
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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