Protective Effect of KB-R7943, a Novel Na^+/Ca^<2+> Exchange Inhibitor, on Ischemic Acute Renal Failure in Rats

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Abstract

The effects of KB-R7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate), a novel Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchange inhibitor, on ischemic acute renal failure (ARF) in rats were examined. ARF was induced by clamping the left renal pedicle for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function was markedly diminished in ARF rats. Pretreatment with KB-R7943 (10 mg/kg, i.v.) markedly attenuated the ARF-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damage, which was suppressed by KB-R7943. Activation of the reverse mode of Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchange seems to play an important role in the pathogenesis of ARF. A selective Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchange inhibitor may be useful in cases of ARF.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(2), 247-251, 1999-10

    The Japanese Pharmacological Society

References:  15

Cited by:  4

Codes

  • NII Article ID (NAID)
    10008197088
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4886750
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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