Role of the Angiotensin II Type-2 Receptor in the Mouse Central Nervous System

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Author(s)

Abstract

There are two known major angiotensin II receptor subtypes, type 1 (AT<SUB>1</SUB>) and type 2 (AT<SUB>2</SUB>), both of which are present in the brain. AT<SUB>1</SUB> and AT<SUB>2</SUB> receptors occur in characteristic distributions that are highly correlated with the distribution of angiotensin II-like immunoreactivity in nerve terminals. Acting through the AT<SUB>1</SUB> receptor in the central nervous system, angiotensin II has effects on fluid and electrolyte homeostasis, neuroendocrine systems, autonomic pathways regulating cardiovascular function and behavior. While the role of the AT<SUB>2</SUB> receptor in the brain is less well understood, recent knockout studies point to their involvement in behavioral and cardiovascular functions. We discuss here evidence regarding the function of the AT<SUB>2</SUB> receptor in the brain, determined using mice lacking the AT<SUB>2</SUB> receptor.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(3), 259-263, 1999-11

    The Japanese Pharmacological Society

References:  33

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008197145
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4918231
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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