Role of the Angiotensin II Type-2 Receptor in the Mouse Central Nervous System.

• Okuyama Shigeru

  1st Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.

• Sakagawa Takashi

  Laboratory of Animal Center, Taisho Pharmaceutical Co., Ltd.

• Inagami Tadashi

  Department of Biochemistry, Vanderbilt University School of Medicine

抄録

There are two known major angiotensin II receptor subtypes, type 1 (AT₁) and type 2 (AT₂), both of which are present in the brain. AT₁ and AT₂ receptors occur in characteristic distributions that are highly correlated with the distribution of angiotensin II-like immunoreactivity in nerve terminals. Acting through the AT₁ receptor in the central nervous system, angiotensin II has effects on fluid and electrolyte homeostasis, neuroendocrine systems, autonomic pathways regulating cardiovascular function and behavior. While the role of the AT₂ receptor in the brain is less well understood, recent knockout studies point to their involvement in behavioral and cardiovascular functions. We discuss here evidence regarding the function of the AT₂ receptor in the brain, determined using mice lacking the AT₂ receptor.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 81 (3), 259-263, 1999

  公益社団法人 日本薬理学会

キーワード

• Angiotensin
• AT<SUB>1</SUB> receptor
• AT<SUB>2</SUB> receptor
• Neuromodulation
• Anxiogenic behavior

詳細情報

• CRID: 1390282679262358528
• NII論文ID: 10008197145
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.81.259
• COI: 1:CAS:528:DyaK1MXns1GntLs%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4918231
• PubMed: 10622213
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4918231
• Web Site: https://www.jstage.jst.go.jp/article/jjp/81/3/81_3_259/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000070692
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可