The Effect of Nipradilol on the Isoproterenol-Induced Depression of Contractions in the Cat Soleus Muscle

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Author(s)

Abstract

The effect of nipradilol on the isoproterelol-induced depression of contractions of the soleus muscle of the anesthetized cats was studied. Isoproterenol (0.3 μg/kg) injected intravenously decreased the tension and degree of fusion of incomplete tetanic contractions of the soleus muscle of the anesthetized cats. The effect of isoproterenol was blocked by nipradilol (≥3 μg/kg), desnitro-nipradilol (≥10 μg/kg) and propranolol (≥10 μg/kg), but not by nitroglycerin (10 - 100 μg/kg). Nipradilol (30 μg/kg) and desnitro-nipradilol (300 μg/kg) almost completely antagonized the depressor effects of isoproterenol. These results coupled with evidence that nipradilol does not penetrate the blood-brain barrier indicate that nipradilol exerts an anti-tremor action by blocking peripheral β<SUB>2</SUB>-adrenoceptors.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(3), 286-291, 1999-11

    The Japanese Pharmacological Society

References:  17

Codes

  • NII Article ID (NAID)
    10008197268
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    4918301
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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