Effects of Toluene on Regulation of Adenylyl Cyclase by Stimulation of G-Protein-Coupled Receptors Expressed in CHO Cells

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Author(s)

Abstract

We determined the effects of toluene exposure on activation or inhibition of adenylyl cyclase by stimulating human β<SUB>2</SUB>-adrenergic receptors (β<SUB>2</SUB>-AR) and muscarinic acetylcholine receptor (mAChR) m2 subtypes, respectively, expressed in CHO cells. The formation of cAMP via β<SUB>2</SUB>-AR stimulation was slightly but not significantly facilitated in the presence of 3.7 μM toluene. On the other hand, the inhibition of adenylyl cyclase by 10 μM of carbamylcholine stimulation of mAChR m2 subtypes was attenuated in the presence of toluene. These results strongly suggest that toluene affects activation of G<SUB>i</SUB> rather than G<SUB>s</SUB>.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(3), 305-308, 1999-11

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008197350
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4918395
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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