On the Inotropic Actions of Arginine Vasopressin in Ventricular Muscle of the Guinea Pig Heart

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Author(s)

Abstract

Arginine vasopressin (AVP) (0.03 - 3 μM) produced transient negative responses that were followed by slowly developing positive inotropic responses in guinea pig papillary muscles. The inotropic responses were antagonized by OPC-21268 (10 μM), but not by OPC-31260, and suppressed by neomycin (3 mM). The negative inotropic response was hardly affected by staurosporine (10 nM) and H-7 (10 μM). AVP (1 μM) elicited a transient decrease followed by a slowly developing increase in I<SUB>Ca</SUB>. The latter increase in I<SUB>Ca</SUB> was not elicited in the presence of staurosporine (1 nM). These results indicate that AVP stimulates V1 receptors that couple to phosphoinositide hydrolysis and thereby increases intracellular Ca<SUP>2+</SUP> and activates protein kinase C.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(3), 309-312, 1999-11

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008197366
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4918420
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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