On the Inotropic Actions of Arginine Vasopressin in Ventricular Muscle of the Guinea Pig Heart.

• Fujisawa Susumu

  Department of Pharmacology, Akita University School of Medicine

• Iijima Toshihiko

  Department of Pharmacology, Akita University School of Medicine

抄録

Arginine vasopressin (AVP) (0.03 - 3 μM) produced transient negative responses that were followed by slowly developing positive inotropic responses in guinea pig papillary muscles. The inotropic responses were antagonized by OPC-21268 (10 μM), but not by OPC-31260, and suppressed by neomycin (3 mM). The negative inotropic response was hardly affected by staurosporine (10 nM) and H-7 (10 μM). AVP (1 μM) elicited a transient decrease followed by a slowly developing increase in I_Ca. The latter increase in I_Ca was not elicited in the presence of staurosporine (1 nM). These results indicate that AVP stimulates V1 receptors that couple to phosphoinositide hydrolysis and thereby increases intracellular Ca²⁺ and activates protein kinase C.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 81 (3), 309-312, 1999

  公益社団法人 日本薬理学会

キーワード

• Vasopressin-1 receptor
• Protein kinase C
• L-type Ca<SUP>2+</SUP> current

詳細情報

• CRID: 1390282679262345088
• NII論文ID: 10008197366
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.81.309
• COI: 1:CAS:528:DyaK1MXns1Gntb0%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4918420
• PubMed: 10622221
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4918420
• Web Site: https://www.jstage.jst.go.jp/article/jjp/81/3/81_3_309/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000082671
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可