Antagonistic Effect of N-Methyltyramine on α_2-Adrenoceptor in Mice

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Author(s)

Abstract

We examined the effect of <I>N</I>-methyltyramine (NMT) on α<SUB>2</SUB>-adrenoceptor. NMT (10<SUP>-8</SUP> - 10<SUP>-3</SUP> M) inhibited the binding of [<SUP>3</SUP>H]<I>p</I>-aminoclonidine to α<SUB>2</SUB>-adrenoceptor dose-dependently. However, the IC<SUB>50</SUB> value for NMT (5.53×10<SUP>-6</SUP> M) was higher than that for RX821002, an α<SUB>2</SUB>-adrenoceptor antagonist (1.07×10<SUP>-8</SUP> M). RX821002 (5 mg/kg, i.p.) inhibited hypermotility induced by scopolamine (8 mg/kg, s.c.) in male ddY mice. NMT (20 or 100 mg/kg, i.p.) was found to have a dose-dependent inhibitory effect similar to that of RX821002. These findings indicate that NMT has the properties of an α<SUB>2</SUB>-adrenoceptor antagonist. However, the affinity of NMT for α<SUB>2</SUB>-adrenoceptor is weaker than that of RX821002.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(3), 313-315, 1999-11

    The Japanese Pharmacological Society

References:  12

Codes

  • NII Article ID (NAID)
    10008197382
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4918446
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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