Receptor-Mediated Modulation of Voltage-Dependent Ca〔2+〕Channels via Heterotrimeric G-proteins in Neurons

• Kaneko Shuji

  Departments of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Akaike Akinori

  Departments of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Satoh Masamichi

  Departments of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University

書誌事項

タイトル別名

• Receptor-Mediated Modulation of Voltage-Dependent Ca2+ Channels via Heterotrimeric G-proteins in Neurons.

抄録

The activity of voltage-dependent Ca²⁺ channels is highly regulated by neurotransmitter receptors coupled to heterotrimeric G-proteins. In the expression studies using cloned Ca²⁺ channel subunits, it has been clarified that the main mechanism of the inhibition of N-type channel current is mediated directly by G-protein βγ subunits in a membrane-delimited and voltage-sensitive manner. In addition, recent studies have also clarified that N-type channels are modulated by several G-protein α subunits in different ways. Among them, G_αo mediates a voltage-resistant inhibition of N-type current by neurotransmitters. This type of inhibition is more apparent in the case of P/Q-type channels in both native cells and expression systems. Moreover, other G-protein subunits, such as G_αq and G_αs, also seem to regulate N-type channels in a membrane-delimited manner. The fine tunings of Ca²⁺ channel activity by intracellular proteins have physiological and pathological meanings in the regulation of Ca²⁺ influx into excitable cells by neurotransmitters and pharmacological implications as novel drug targets for controlling Ca²⁺ influx.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 81 (4), 324-331, 1999

  公益社団法人 日本薬理学会

キーワード

• Voltage-dependent Ca<SUP>2+</SUP> channel
• GTP-binding protein
• N-type
• P/Q-type

詳細情報

• CRID: 1390001204284683008
• NII論文ID: 10008197430
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.81.324
• COI: 1:CAS:528:DC%2BD3cXhtFGrsQ%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4948488
• PubMed: 10669036
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4948488
• Web Site: https://www.jstage.jst.go.jp/article/jjp/81/4/81_4_324/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000140385
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可