Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats

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Author(s)

Abstract

The place preferences by some histamine H<SUB>1</SUB> antagonists, such as tripelennamine, optical isomers of chlorpheniramine (<I>dl</I>-, <I>d</I>- and <I>l</I>-forms) and pyrilamine, in rats were evaluated with the conditioned place preference paradigm. In the present study, tripelennamine and all of the optical isomers of chlorpheniramine, but not pyrilamine, produced a significant place preference. The degree of the place preference induced by optical isomers of chlorpheniramine (6.0 mg/kg) did not correlate with the H<SUB>1</SUB>-antagonistic potency of these drugs, suggesting that H<SUB>1</SUB>-antagonist-induced place preferences are not mediated by H<SUB>1</SUB>-receptor blockade. The tripelennamine (3.0 mg/kg)- and <I>dl</I>-chlorpheniramine (6.0 mg/kg)-induced place preferences were completely abolished by pretreatment with the dopamine D<SUB>1</SUB>-receptor antagonist SCH23390 (0.05 mg/kg). Furthermore, the doses of H<SUB>1</SUB> antagonists that induced a place preference significantly reduced the levels of DOPAC, which may be mediated by inhibition of dopamine uptake, in the limbic forebrain (including the nucleus accumbens and olfactory tubercle). These results suggest that some H<SUB>1</SUB> antagonists induce rewarding effects, which may be mediated by the activation of dopamine D<SUB>1</SUB> receptors, followed by the inhibition of dopamine uptake.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(4), 332-338, 1999-12-01

    The Japanese Pharmacological Society

References:  46

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008197486
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4948496
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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