Effect of Benidipine on Depolarizing Stimulation-Induced Increase of Intracellular Calcium Concentration in Cultured Mouse Hippocampal Neurons

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Author(s)

Abstract

We examined the effect of benidipine, a 1, 4-dihydropyridine calcium channel blocker, on depolarizing stimulation-induced increases of intracellular calcium concentration ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) in cultured mouse hippocampal neurons in comparison with those of nicardipine and nilvadipine. Benidipine (0.1 - 10 μM) inhibited the [Ca<SUP>2+</SUP>]<SUB>i</SUB> increase compared with the no drug control response. This effect was stronger than those of nicardipine and nilvadipine. The inhibitory effect of benidipine lasted even after washing out the drug for 125 min, while those of nicardipine and nilvadipine disappeared more rapidly. This is the first report that demonstrates that benidipine inhibits the [Ca<SUP>2+</SUP>]<SUB>i</SUB> increase in the neuron itself.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 81(4), 401-403, 1999-12-01

    The Japanese Pharmacological Society

References:  12

Codes

  • NII Article ID (NAID)
    10008197807
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4948644
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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