Effect of Benidipine on Depolarizing Stimulation-Induced Increase of Intracellular Calcium Concentration in Cultured Mouse Hippocampal Neurons

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抄録

We examined the effect of benidipine, a 1, 4-dihydropyridine calcium channel blocker, on depolarizing stimulation-induced increases of intracellular calcium concentration ([Ca<SUP>2+</SUP>]<SUB>i</SUB>) in cultured mouse hippocampal neurons in comparison with those of nicardipine and nilvadipine. Benidipine (0.1 - 10 μM) inhibited the [Ca<SUP>2+</SUP>]<SUB>i</SUB> increase compared with the no drug control response. This effect was stronger than those of nicardipine and nilvadipine. The inhibitory effect of benidipine lasted even after washing out the drug for 125 min, while those of nicardipine and nilvadipine disappeared more rapidly. This is the first report that demonstrates that benidipine inhibits the [Ca<SUP>2+</SUP>]<SUB>i</SUB> increase in the neuron itself.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 81(4), 401-403, 1999-12-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008197807
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4948644
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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