Inhibition of Human Chymase by Suramin.

• Takao Kazumasa

  Department of Pharmacology, Osaka Medical College Discovery Research Division, Santen Pharmaceutical Co., Ltd.

• Takai Shinji

  Department of Pharmacology, Osaka Medical College

• Ishihara Takafumi

  Discovery Research Division, Santen Pharmaceutical Co., Ltd.

• Mita Shiro

  Discovery Research Division, Santen Pharmaceutical Co., Ltd.

• Miyazaki Mizuo

  Department of Pharmacology, Osaka Medical College

抄録

Chymase is a chymotrypsin-like protease localized in mast cells in complexes with heparin. In the present study, we demonstrated that suramin, a hexasulfonated naphthylurea used as an anti-cancer drug, inhibits the activity of purified human chymase in vitro. The inhibition was ionic-strength-dependent. It was observed that suramin competed with heparin-Sepharose gel for binding to chymase and the inhibition of chymase activity by suramin was partially impaired by heparin. Our results show that suramin may become a prototype of a new type of chymase inhibitor because of its unique character.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 81 (4), 404-407, 1999

  公益社団法人 日本薬理学会

キーワード

• Chymase
• Suramin
• Heparin

詳細情報

• CRID: 1390282679261399168
• NII論文ID: 10008197820
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.81.404
• COI: 1:CAS:528:DC%2BD3cXhtFGqtA%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4948651
• PubMed: 10669049
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4948651
• Web Site: https://www.jstage.jst.go.jp/article/jjp/81/4/81_4_404/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000142622
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可