Absorption and Excretion of OPB-2045 following a Single Oral Administration to Rats.

• KUDO Shoji

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd

• IWASAKI Minoru

  Laboratory of Pharmacokinetics & Pharmacology, Panapharm Laboratories

• SUGIMOTO Kenji

  Laboratory of Pharmacokinetics & Pharmacology, Panapharm Laboratories

• KODAMA Ryuhei

  Laboratory of Pharmacokinetics & Pharmacology, Panapharm Laboratories

• ODOMI Masaaki

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd

抄録

The absorption and excretion of radioactivity were investigated in Sprague-Dawly rats following a single oral administration of ¹⁴C-labeled OPB-2045, and the following results were obtained:<BR> 1. Serum levels of radioactivity reached the maximum of 0.09-0.11μg eq. /ml at 30 min in male and female rats after oral administration of ¹⁴C-OPB-2045 at 10 mg/kg. The half-life of radioactivity in serum was 5.9-8.6 hr as determined at 2 hr to 24 hr after administration. AUC_0-infinite was 0.46-0.59 μg eq.·hr/ml. Radioactivity in blood cells accounted for 7.5-53.1% of total radioactivity in the blood.<BR> 2. Urinary and fecal excretion of radioactivity was 1.2-4.6% and 92.1-94.5% of the administered dose, respectively, in rats receiving oral doses of 10 mg/kg. Biliary excretion of radioactivity was 2.9% of the dose within 24 hr after oral administration.<BR> 3. No sex difference in absorption or excretion of ¹⁴C-OPB-2045 was observed in rats after oral administration of the compound.

収録刊行物

• 薬物動態

  薬物動態 13 (4), 325-329, 1998

  日本薬物動態学会

キーワード

• OPB-2045
• Absorption
• Excretion
• Rat

詳細情報

• CRID: 1390001204668288512
• NII論文ID: 10008198555
• NII書誌ID: AN10144117
• DOI: 10.2133/dmpk.13.325
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/13/4/13_4_325/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999001490
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可