Validation Studies of Radioluminography. I. Measurement of Background Value.

• BABA Shigeo

  Nemoto Life Science Laboratories, Nemoto & Co., Ltd

• ASAHARA Nobumitsu

  Nemoto Life Science Laboratories, Nemoto & Co., Ltd

• IIDA Satofumi

  Nemoto Life Science Laboratories, Nemoto & Co., Ltd

• TOMISAWA Hiroki

  Nemoto Life Science Laboratories, Nemoto & Co., Ltd

• TATEISHI Mitsuru

  Nemoto Life Science Laboratories, Nemoto & Co., Ltd

• MIYAZAKI Hiroshi

  Niigata College Pharmacy

Abstract

A basic study was carried out in order to improve the detection accuracy of radioluminography (RLG) in drug evaluation studies. Back ground value of photo-stimulated luminescence (PSL_BG) of an imaging plate (IP) was proven to decrease exponentially in proportion to the wall thickness of exposure vessels without any improvement of SD of PSL_BG. This unexpected result was attributed to the fact that a nonuniformity in shielding occurred. PSL_BG was estimated in terms of β-particles from ³²P. When IP was exposed in a shield box, a clear periodicity was observed in the PSL_BG. A method for directly measuring the PSL_BG of each area was developed, which involved exposing IPs simultaneously and assessing PSLBG of the IP in contact with a ¹⁴C sample from the PSL_BG of the corresponding area of the other IPs.

Journal

• Drug Metabolism and Pharmacokinetics

  Drug Metabolism and Pharmacokinetics 13 (6), 566-571, 1998

  The Japanese Society for the Study of Xenobiotics

Keywords

• Validation
• Radioluminography
• Imaging plate (IP)
• Bio-imaging analyzer system (BAS)
• Correction of background value

Details

• CRID: 1390282679644840960
• NII Article ID: 10008199060
• NII Book ID: AN10144117
• DOI: 10.2133/dmpk.13.566
• ISSN: 09161139
• Web Site: http://www.jstage.jst.go.jp/article/dmpk1986/13/6/13_6_566/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999112211
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed