An Implication of Molecular Mechanism for Eliciting Sweetness of Anionic β-Glycyrrhetinic Acid Derivatives

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Author(s)

Abstract

Anionic derivatives of β-glycyrrhetinic acid (GA) containing a carboxylate- and a sulfate-terminated substituent at the C-3 position were prepared and assessed for their relative sweetness. A molecular mechanism for sweet taste expression of these derivatives was discussed assuming CPK molecular models of the N-terminal α-helix fragment of the T1R3 protein, which was a likely candidate for the binding site of GA derivatives and helped well explain their sweetness.

Journal

  • Journal of Oleo Science

    Journal of Oleo Science 51(5), 313-321, 2002-05-01

    Japan Oil Chemists' Society

References:  28

Codes

  • NII Article ID (NAID)
    10008224234
  • NII NACSIS-CAT ID (NCID)
    AA11503337
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13473352
  • NDL Article ID
    6140708
  • NDL Source Classification
    ZP25(科学技術--化学・化学工業--油脂類)
  • NDL Call No.
    Z54-J571
  • Data Source
    CJP  NDL  J-STAGE 
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