An Implication of Molecular Mechanism for Eliciting Sweetness of Anionic .BETA.-Glycyrrhetinic Acid Derivatives.

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  • TOYOSHIMA Toshinobu
    Department of Bioapplied Chemistry, Graduate School of Engineering, Osaka City University
  • FUJIHARA Masahiro
    Department of Bioapplied Chemistry, Graduate School of Engineering, Osaka City University
  • TAMAGAKI Seizo
    Department of Bioapplied Chemistry, Graduate School of Engineering, Osaka City University

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  • An Implication of Molecular Mechanism for Eliciting Sweetness of Anionic β-Glycyrrhetinic Acid Derivatives
  • Implication of Molecular Mechanism for Eliciting Sweetness of Anionic ベータ Glycyrrhetinic Acid Derivatives

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Abstract

Anionic derivatives of β-glycyrrhetinic acid (GA) containing a carboxylate- and a sulfate-terminated substituent at the C-3 position were prepared and assessed for their relative sweetness. A molecular mechanism for sweet taste expression of these derivatives was discussed assuming CPK molecular models of the N-terminal α-helix fragment of the T1R3 protein, which was a likely candidate for the binding site of GA derivatives and helped well explain their sweetness.

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