Preparation of Oligosaccharide Units Library Utilizing Enzyme-catalyzed Glycosylation.

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  • Murata Takeomi
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • Usui Taichi
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

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  • 酵素法によるオリゴ糖鎖ライブラリーの構築
  • コウソホウ ニ ヨル オリゴ トウサ ライブラリー ノ コウチク

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Abstract

With the growing biological importance of oligosaccharides involved in glycoconjugates, practical synthetic methods for obtaining oligosaccharides have been required. Enzyme-catalyzed oligosaccharide synthesis has been shown to be one of the most effective methods for large-scale oligo-saccharide synthesis. This review describes enzyme-catalyzed synthesis of di, tri, and tetrasaccharide units, which are related to biological roles: (1) galactose-containing disaccharides, (2) fucosecontaining trisaccharides, (3) core oligosaccharides in mucin-type carbohydrate, and (4) human milk oligosaccharides. Such well-defined oligosaccharide units are useful as substrates for glycosidases and glycosyltransferases, and as starting materials for artificial glycopolymers, which are valuable as probes of carbohydrate-protein interaction.

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