サイクロデキストランとサイクロデキストリンの溶解特性および包接特性の比較 Comparison of the Solubility and Inclusion Characteristics of Cyclodextran with Cyclodextrin

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Abstract

サイクロデキストラン(CI-7, CI-8, CI-9)の溶解特性およびいくつかの包接特性をサイクロデキストリン(CD)と比較した. CIは水に対する溶解性がきわめて高いが,CI-9は80%土タノール, n一プロバノールで容易に沈澱した.CIはTrpとの反応性がCDよりも高かった.CDは各種の界面活性剤と反応して著量の沈澱を生じたが,CIの反応性は小さいことがわかった.CIの反応系にエタノール,アセトニトリル(73%)を添加すると沈澱の生成は著しく促進されたことから,CIの溶解性を低下させると包接反応が亢進されるものと推定された.α一グルコシダーゼによる基質のフェニル-α一グルコシドの分解はCIにより抑制されたが,CDの添加では逆に分解反応が強くなるとの結果が得られた.

The solubility and some inclusion characteristics of the newly developed sugar, cyclodextran (cyclic isomaltooligosaccharides: heptamer, CI-7; octamer, CI-8; nonamer, CI-9), were compared with those of cyclodextran (CD: hexamer, α-CD; heptamer, β-CD; octamer, γ-CD). In spite of the high solubility of CI in water, CI-9 was readily precipitated by mixing with 80% ethanol and n-propanol. Rather higher interactions of CIs with Trp than CDs were observed. Although CDs gave higher amounts of precipi-tate upon reaction with various surfactants, the interaction of CIs with surfactants was rather poor. The precipitate formation of CIs was greatly improved by the addition of 73% ethanol or acetonitrile, suggesting that a decrease in the solubility of CIs would lead to an increase in inclusion reactions. The action of α-glucosidase on the substrate phenyl a-glucoside was inhibited by CIs, while CDs gave opposite results accelerating the enzyme reaction.

Journal

  • Journal of Applied Glycoscience

    Journal of Applied Glycoscience 45(3), 255-259, 1998-08-31

    The Japanese Society of Applied Glycoscience

References:  19

Codes

  • NII Article ID (NAID)
    10008258261
  • NII NACSIS-CAT ID (NCID)
    AN10453916
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    13403494
  • NDL Article ID
    4551726
  • NDL Source Classification
    ZP24(科学技術--化学・化学工業--糖・澱粉)
  • NDL Call No.
    Z17-15
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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