Synthesis and Properties of Hetero-branched Cyclodextrins.
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- Hamayasu Kenichi
- Bio Research Corporation of Yokohama
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- Hara Koji
- Bio Research Corporation of Yokohama
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- Fujita Koki
- Bio Research Corporation of Yokohama
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- Hashimoto Hitoshi
- Bio Research Corporation of Yokohama
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- Matsuda Kazuha
- School of Pharmaceutical Sciences, Mukogawa Women's University
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- Okada Yasuyo
- School of Pharmaceutical Sciences, Mukogawa Women's University
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- Tanimoto Toshiko
- School of Pharmaceutical Sciences, Mukogawa Women's University
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- Koizumi Kyoko
- School of Pharmaceutical Sciences, Mukogawa Women's University
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- Nakano Hirofumi
- Osaka Municipal Technical Research Institute
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- Kitahata Sumio
- Osaka Municipal Technical Research Institute
Bibliographic Information
- Other Title
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- ヘデロ分岐シグロデキストリンの合成とその性質
- ヘテロ分岐シクロデキストリンの合成とその性質
- ヘテロ ブンキ シクロデキストリン ノ ゴウセイ ト ソノ セイシツ
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Abstract
Hetero-branched cyclodextrins (CDs) were synthesized by transglycosylation or the reverse action of several enzymes such as βββ-galactosidases, α-galactosidases, α-mannosidases, lysozyme and R-Nacetylhexosaminidase. Their structures were analyzed by methylation, FAB-MS, and NMR spectroscopies. β-Galactosidase and a-galactosidase from microorganisms synthesized hetero-branched CDs, of which the galactose residues were linked at side chains of the branched CDs. But these enzymes could not synthesize galactosyl-CDs, directly linked to the CD ring. However, α-galactosidase from coffee bean and α-mannosidase and N-acetylhexosaminidase from jack bean could bind galactosyl, mannosyl and N-acetylglucosaminyl residues directly to the CD rings, respectively, by transglycosylation or reverse action. The effects of the side-chain residues in branched CDs, on solubility, hemolytic activity, and inclusion reactions with 6-O-α-D-glucosyl-CDs, 6-O-α-D-galactosyl-CDs, and 6-O-α-Dmannosyl-CDs, were examined.
Journal
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- Journal of Applied Glycoscience
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Journal of Applied Glycoscience 46 (2), 217-225, 1999
The Japanese Society of Applied Glycoscience
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Details 詳細情報について
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- CRID
- 1390282681268969600
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- NII Article ID
- 10008259068
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- NII Book ID
- AN10453916
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- ISSN
- 18807291
- 13447882
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- NDL BIB ID
- 4785936
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed