New Types of Liposidomycins Which Inhibit Bacterial Peptidoglycan Synthesis Produced by Streptomyces.

• Kagami Shinobu

• Kimura Ken-ichi

• Ikeda Yoshikazu

• Takahashi Hidetoshi

• Kusakabe Hiroo

• Osada Hiroyuki

• Isono Kiyoshi

• Yoshihama Makoto

Abstract

Liposidomycins are atypical lipid-bearing nucleoside antibiotics that inhibit bacterial peptidoglycan synthesis. A producing strain was identified as a Streptomyces sp. from its cultural characteristics and physiological properties. It produced new types of liposidomycins that lacked sulfate and/or 3-methylglutaric acid moieties present in known liposidomycins by changing medium components. Liposidomycins which have no sulfate moiety, exhibited more potent antimicrobial activity. Thus liposidomycins are the unique antibiotics showing highly specific inhibition toward bacterial peptidoglycan synthesis and could be a useful clinical antibiotic agent.

Journal

• Actinomycetologica

  Actinomycetologica 12 (2), 110-119, 1998

  The Society for Actinomycetes Japan

Keywords

• General Medicine

Details

• CRID: 1390282679679429760
• NII Article ID: 130004487482
• NII Article ID: 10008263046
• NII Book ID: AN10080091
• DOI: 10.3209/saj.12_110
• COI: 1:CAS:528:DyaK1MXitF2lurs%3D
• ISSN: 18816371
• ISSN: 09145818
• NDL BIB ID: 3087031
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3087031
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed