Changes of Sex Steroids and Prostaglandins at Inhibition of Ovulation by Inhibitor of Prostaglandin Biosynthesis in the Gilts.

• YAMADA Yutaka

  Hokkaido National Agricultural Experiment Station

• KAWAI Yasuo

  Faculty of Medecine, Tokyo University Present address: Kawai Clinic

Bibliographic Information

Other Title

• プロスタグランジン生合成酵素阻害剤による排卵抑制時の性ステロイドおよびプロスタグランジンの動態
• プロスタグランジン セイゴウセイ コウソ ソガイザイ ニ ヨル ハイラン ヨクセイジ ノ セイ ステロイド オヨビ プロスタグランジン ノ ドウタイ

Abstract

The present study was conducted to clarify the changes of sex steroids and Prostaglandins at inhibition of ovulation by an inhibitor of Prostaglandin biosynthesis in the prepubertal gilts. Thirty prepubertal gilts were injected intramuscularly with hCG (6IU/kg of body weight; kg. b. w.) 72 hours after receiving PMSG (12IU/kg. b. w.). Twentyfour hours after hCG injection, they were injected intramuscularly either phisiological saline solution (Control Group; n=15) or 7.6mg/kg. b. w of indomethacin (Indomethacin Group; n=15). In each ten gilts of both groups, the ovulation was verified by laparotomy on 2, 3 or 7 days after hCG injection, respectively. In each five gilts of both groups, blood sample was withdrawn from jugular vein until 25 days after hCG injection and levels of sex steroids were measured.<br>The patterns of the changes in the levels of Progesterone, Estradiol-17β and Testosterone in peripheral blood plasma and ovarian vein blood plasma were similar in Control and Indomethacin Group. In Indomethacin Group, ovarian follicular fluid was in ovarian follicle even on the 7th day after hCG injection. The concentration of progesterone in follicular fluid was very high. The concentration of PGE₁ and PGF_2α in follicular fluid did not increase and remained low level.<br>The patterns of the changes in the levels of Progesterone, Estradiol-17β and Testosterone in peripheral blood plasma for 25 days after hCG injection were not different in both Control and Indomethacin Group. The life span of corpus luteum was 18 days in Control and Indomethacin Group, respectively. Based on these results, it is suggested that inhibition of ovulation by indomethacin did not influence steroidogenesis in ovarian follicle. It is also suggested that prostaglandins take part in some roles in the phenomenon of rupture of follicle.

Journal

• Nihon Yoton Gakkaishi

  Nihon Yoton Gakkaishi 36 (3), 117-123, 1999

  The Japanese Society of Swine Science

Keywords

• Inhibition of ovulation
• Sex steroids
• Prostaglandins
• Immature gilts
• Indomethacin

Details

• CRID: 1390001204707444736
• NII Article ID: 10008285343
• NII Book ID: AN10202971
• DOI: 10.5938/youton.36.117
• ISSN: 1881655X
• ISSN: 0913882X
• NDL BIB ID: 4879029
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010600757
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4879029
• Text Lang: ja
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed