心不全におけるβ遮断薬の有効性 β-adrenergic Receptor Blockade in Heart Failure

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著者

    • 上地 正実 UECHI Masami
    • 北里大学獣医畜産学部附属動物病院 Animal Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University

抄録

The failing heart is adrenergically activated, which helps to maintain cardiac performance over the short term by increasing contractility and heart rate. Multiple lines of evidence indicate that it is the increase in cardiac adrenergic drive rather than an increase in circulating norepinephrine that is both initially supportive and then ultimately damaging to the failing heart. The continuously increased adrenergic drive present in the failing heart delivers adverse biological signals to the cardiac myocyte via β<sub>1</sub>-and β<sub>2</sub>-adrenergic receptors. Thus, β-adrenergic receptor blocking agents produce clinical and hemodynamic improvement in severe heart failure.

収録刊行物

  • 動物の循環器 = Advances in animal cardiology

    動物の循環器 = Advances in animal cardiology 33(2), 41-46, 2000-12-01

    獣医循環器研究会

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各種コード

  • NII論文ID(NAID)
    10008286326
  • NII書誌ID(NCID)
    AN10192925
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09106537
  • NDL 記事登録ID
    5757718
  • NDL 雑誌分類
    ZR22(科学技術--農林水産--畜産)
  • NDL 請求記号
    Z18-1508
  • データ提供元
    CJP書誌  NDL  IR  J-STAGE 
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