心不全におけるβ遮断薬の有効性  [in Japanese] β-adrenergic Receptor Blockade in Heart Failure  [in Japanese]

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Author(s)

    • 上地 正実 UECHI Masami
    • 北里大学獣医畜産学部附属動物病院 Animal Teaching Hospital, School of Veterinary Medicine & Animal Science, Kitasato University

Abstract

The failing heart is adrenergically activated, which helps to maintain cardiac performance over the short term by increasing contractility and heart rate. Multiple lines of evidence indicate that it is the increase in cardiac adrenergic drive rather than an increase in circulating norepinephrine that is both initially supportive and then ultimately damaging to the failing heart. The continuously increased adrenergic drive present in the failing heart delivers adverse biological signals to the cardiac myocyte via β<sub>1</sub>-and β<sub>2</sub>-adrenergic receptors. Thus, β-adrenergic receptor blocking agents produce clinical and hemodynamic improvement in severe heart failure.

Journal

  • Advances in Animal Cardiology

    Advances in Animal Cardiology 33(2), 41-46, 2000-12-01

    Japanese Society of Veterinary Cardiology

References:  10

Codes

  • NII Article ID (NAID)
    10008286326
  • NII NACSIS-CAT ID (NCID)
    AN10192925
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    09106537
  • NDL Article ID
    5757718
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-1508
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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