高齢犬における大動脈の病理学的検索  [in Japanese] Histopathologic Features of The Aorta in Aged Dogs  [in Japanese]

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Author(s)

    • 向井 真 MUKAI Shin
    • 東京農工大学農学部家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 樫田 陽子 KASHIDA Yoko
    • 東京農工大学農学部家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 町田 登 MACHIDA Noboru
    • 東京農工大学農学部家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 中村 孝 NAKAMURA Takashi
    • 東京農工大学農学部家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 桐生 啓治 KIRYU Keiji
    • 東京農工大学農学部家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology

Abstract

高齢犬20例(10-18歳)を対象として,大動脈各部の病理学的検索を行なった。肉眼的に17例の大動脈の内膜面に粗造感が認められ,そのうち6例は内膜面に丘陵状の白斑形成を伴っていた。顕微鏡的には内膜,内弾性板および中膜に病理組織学的変化が観察された。内膜には著明な肥厚がみられ,その内膜肥厚を構成する主要な成分によって(i)平滑筋細胞主体,(ii)膠原線維主体,(iii)平滑筋細胞および膠原線維の両者による二層構造を示す内膜肥厚の3つに大別された。内弾性板には部分的消失,断裂,細片化,重複化,石灰沈着などの変化がみられ,内膜病変に随伴していた。中膜においては水腫性変化,膠原線維増生,線維化が,一連の過程として観察された。特に中膜の線維化は,内膜肥厚が顕著な例に多く見出された。内膜,内弾性板及び中膜の各病変は,加齢に伴い,また,近位部から遠位部に向かうに従って重篤さを増す傾向を示した。今回観察された大動脈の形態学的変化は,ヒトの老齢性動脈硬化症にみられる病変と一致していた。

The aorta was examined pathologically in 20 dogs ranging in age from 10 to 18 years. Macroscopically, rough appearance of the intimal surface of the aorta was found in 17 dogs : 6 animals showed white linear or streak-like plaque formation on the intimal surface. Microscopically, many portions of the aorta examined exhibited degenerative or sclerotic changes in the intima, internal elastic membrane and media. Intimal lesions characterized by mild to severe thickening were classified into 3 types according to their main components : muscular, fibrous and fibromuscular thickening. An alteration in the internal clastic membrane consisted of partial loss, splitting, fragmentation, reduplication, and calcium deposition, and almost always coexisted together with the intimal lesions in most sections. In the media, edematous swelling of the smooth muscle cells surrounded by edematous accumulation was observed as the earliest evidence of the medial degeneration, which was followed by the presence of relatively dense fibrous tissue with a focal loss of muscle, leading to extensive medial fibrosis. These fibrotic lesions were more frequently observed in the cases with pronounced intimal thickening. The severity of such lesions in the vascular walls appeared to be associated with increasing age. In addition, the severer lesions tended to occur frequently at more distal portions of the aorta. The vascular changes observed in the present study resembled those seen in senile arteriosclerosis in man.

Journal

  • Advances in Animal Cardiology

    Advances in Animal Cardiology 28(1), 17-26, 1995-06

    Japanese Society of Veterinary Cardiology

References:  22

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008286771
  • NII NACSIS-CAT ID (NCID)
    AN10192925
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    09106537
  • Data Source
    CJP  CJPref  J-STAGE  JASI 
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