自然発生性の不整脈を有するニワトリにおける心臓の病理学的研究  [in Japanese] Cardiopathological Study in Chickens with Spontaneously Occurring Arrhythmia  [in Japanese]

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Author(s)

    • 向井 真 MUKAI Shin
    • 東京農工大学農学部獣医学科家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 町田 登 MACHIDA Noboru
    • 東京農工大学農学部獣医学科家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 西村 昌晃 NISHIMURA Masaaki
    • 東京農工大学農学部獣医学科家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 稲垣 秀晃 INAGAKI Hideaki
    • 東京農工大学農学部獣医学科家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 中村 孝 NAKAMURA Takashi
    • 東京農工大学農学部獣医学科家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology
    • 桐生 啓治 KIRYU Keiji
    • 東京農工大学農学部獣医学科家畜病理学教室 Department of Veterinary Pathology, Faculty of Agriculture, Tokyo University of Agriculture and Technology

Abstract

我々はこれまでにロードアイランドレッド種(RIR)を含む5品種のニワトリを用いて自然発生性不整脈の検索を実施した結果,他の品種に比べて各種不整脈がRJRにおいて有意に高率に発生していることを見出した。そこでRIRにおける不整脈の好発性の原因を明らかにするために,RIRの不整脈例(心室性期外収縮,心室頻拍,心室早期興奮症侯群,心房性期外収縮,心房細動)18羽とシャモ種(JG)の不整脈例(心室早期興奮症侯群,心房性期外収縮)4羽,ならびにRIRを含む4品種[RJR,JG,白色レグホン種(WL),RIRとJGとの交雑第一代(RIR×JG)]の正常洞調律例161羽を用いて心臓および心臓外心臓神経の病理学的検索を実施した。<BR>心臓に観察された主な病変は,壁内冠状動脈における細胞性あるいは細胞・線維性内膜肥厚とそれらに随伴して認められた間質性および血管周囲性の心筋線維化であった。重度の血管病変は不整脈例の22羽中16羽(72.7%. RIR:83.3%., JG:25.0%)に,そして正常洞調律例の161羽中27羽(16.8%.RIR:48.5%, JG:8.2%, WL:13.6%, RIR×JG:2.9%)に観察された。また,心筋線維化はRIRの不整脈例18羽中17羽に,JGの不整脈例4羽中1羽に,正常洞調律例ではRIRの33羽中7羽,JGの49羽中2羽,WLの44羽中1羽に認められた。重度血管病変の発生率について不整脈の有無および品種間で比較したところ,RIRの不整脈例はJGの不整脈例およびRIRの正常洞調律例よりも有意に高い発生率を示した(p<0.05)。また,重度血管病変は正常洞調律例においてもRIRが他の品種よりも有意に高い発生率を示した(p<0.001)。一方,心臓外心臓神経には神経線維束のごく軽度の水腫性粗鬆化と石灰沈着が観察されたにすぎなかった。<BR>以上の結果から,RIRにおいて壁内冠状動脈の硬化性変化がより高率に見出された現象が,RIRにおける不整脈の好発性に関わっていた可能性が指摘された。

In our previous study, we found that Rhode Island Red chickens (RIR) showed the highest incidences of spontaneously occurring arrhythmias among seven breeds of chickens. The present study was carried out in the hope of defining the pathology of the heart and extrinsic cardiac nerves in 18 RIR showing ventricular premature depolarization, ventricular tachycardia, ventricular preexcitation, atrial premature depolarization or atrial fibrillation, 4 Japanese Game chickens (JG) with ventricular preexcitation or atrial premature depolarization and 161 chickens of four different breeds (RIR, White Leghorn (WL), JG and the first filial generation obtained by mating RIR with JG (RIRxJG)) with normal sinus rhythm as controls. Microscopically predominant changes in the heart were vascular lesions of the intramural coronary artery. The vascular lesions consisted of intimal thickening with muscular or fibromuscular proliferation. In addition, the lesions were frequently accompanied by narrowing of the vascular lumen and interstitial and perivascular fibrosis. Severe vascular lesions were observed in 16 out of 22 chickens with arrhythmia (72.7% ; RIR : 83.3% and JG : 25.0%) and 27 out of 161 chickens with normal sinus rhythm (16.8%; RIR : 48.5%; JG : 8.2%, WL : 13.6%; RIRxJG : 2.9%). Moreover, foci of myocardial fibrosis were present in greater or lesser numbers depending on the severity of the lesions in both arrhythmia-affected chickens and ones with normal sinus rhythm. The former included17 of the 18 RIR and 1 of the 4 JG, and the latter 7 of 33 RIR, 2 of 39 JG and 1 of 44 WL. The rate of occurrence of the severe vascular lesions was significantly higher in RIR with arrhythmia than in JG with arrhythmia (p<0.05) and in RIR with arrhythmia than in RIR with normal sinus rhythm (p<0.05). Among chickens with normal sinus rhythm, RIR showed a significantly higher incidence of severe vascular lesions than all other breeds (p<0.001) as well. On the other hand, the extrinsic cardiac nerves showed foci of mild lesions consisting of edematous loosening in part of the nerve bundles, and partial deposits of calcium salts were observed in extrinsic cardiac nerves in a few animals. The presence of these nerve lesions appeared to be unrelated to the occurrence of arrhythmia. Our results indicate that the high incidence of arteriosclerosis of the intramural coronary artery may be related to the high incidence of arrhythmia in RIR.

Journal

  • Advances in Animal Cardiology

    Advances in Animal Cardiology 28(2), 95-106, 1995-12-01

    Japanese Society of Veterinary Cardiology

References:  29

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008286872
  • NII NACSIS-CAT ID (NCID)
    AN10192925
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    09106537
  • Data Source
    CJP  CJPref  J-STAGE  JASI 
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