犬の慢性心不全に対するTDK-36(木防已湯)の臨床応用  [in Japanese] Clinical Application of TKD-36 (Moku-boi-to) on Chronic Heart Failure in Dogs  [in Japanese]

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Author(s)

    • 小山 秀一 KOYAMA Hidekazu
    • 日本獣医畜産大学獣医内科学教室 Department of Veterinary Internal Medicine, Nippon Veterinary and Animal Science University
    • 竹村 直行 TAKEMURA Naoyuki
    • 日本獣医畜産大学獣医内科学教室 Department of Veterinary Internal Medicine, Nippon Veterinary and Animal Science University

Abstract

犬の慢性心不全(僧帽弁閉鎖不全症,フィラリア症および拡張型心筋症)に対するTKD-36(木防已湯)の有効性,安全性,有用性および至適投与量を検討するため多施設共同の臨床試験を実施した。TKD-36(75,150および300mg/kg/day)とプラセは,1日2回に分け,4週間経口投与した。その結果,TKD-36の150および300mg/kg/dayは,慢性心不全と診断された犬の臨床所見,身体所見,心不全重症度および胸部X線像をプラセボ群と比較して有意に改善あるいは軽快させたが,75mg/kg/day群では有意な差が認められなかった。安全度については,いずれの投与群においても重篤な副作用を認めず,TKD-36の高い安全性が確認された。<BR>また,TKD-36各投与群間の改善度,安全度および有用度を比較した結果,TKD-36の至適投与量は150ないし300mg/kg/dayと考えられた。<BR>以上の結果から,TKD-36は犬の慢性心不全に対して有効かつ安全な薬剤であると判断された。

A multi-central clinical trial was conducted to assess the effect of TKD-36 (Moku-boi-to)on chronic heart failure in dogs. TKD-36 (75, 150 or 300 mg/kg/day, divided b. i. d., p. o.) or placebo were administered for 4 weeks to dogs showing signs of chronic heart failure. Overall assessment and various clinical evaluation of clinical symptoms in dogs treated with TKD-36 (150 and 300 mg/kg/day) were excellent compared to that in dogs treated with the placebo. But the dose of 75 mg/kg/day of TKD-36 did not improve any clinical signs of heart failure as same as the placebo group. No adverse reactions attributable to TKD-36 administration were observed, confirming its safety in this species. Based on efficacy, safety and overall assessment analyses, the optimal dosage of TKD-36 is from 150 to 300 mg/kg/day.<BR>These results clearly indicate that TKD-36 is an excellent drug for a treatment of the chronic heart failure in dogs.

Journal

  • Advances in Animal Cardiology

    Advances in Animal Cardiology 29(2), 59-78, 1996-12-01

    Japanese Society of Veterinary Cardiology

References:  9

Codes

  • NII Article ID (NAID)
    10008286971
  • NII NACSIS-CAT ID (NCID)
    AN10192925
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    09106537
  • NDL Article ID
    4107691
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-1508
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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