若齢期心筋症ハムスターの形態学的,血液生化学的および心電図学的特徴  [in Japanese] Characterization of Morphological, Biochemical and Electrocardiological Assessments in Young Cardiomyopathic Hamsters  [in Japanese]

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Abstract

若齢期における心筋症ハムスターの特徴を明らかにする目的で形態学的,血液生化学的および心電図学的観点から研究を行い,健常ハムスターの成績と比較検討した。<BR>1)形態学的検討<BR>心臓および腎臓の体重に対する相対重量は心筋症ハムスターの方が有意に重かった。<BR>2)血液生化学的検討<BR>血漿中CPK,GOTおよびGPT値は心筋症ハムスターの方が顕著に高値を示した。<BR>3)心電図学的検討<BR>心電図学的には不整脈を含め若齢期心筋症ハムスターにおいて同月齢の健常ハムスターに比し,特徴的な異常は認められなかった。興奮伝導時間に関してR-R間隔およびPQ間隔は心筋症ハムスターの方が短く,QT間隔は長かった。<BR>これらの結果から,若齢期における心筋症ハムスターの心臓は形態学的には既に心肥大を発症し血液生化学的にも心筋に障害の発生している可能性を示唆しているが,電気生理学的異常は軽微であると考えられた。

The purpose of this study was to clarify the morphologic, biochemical and electrocardiographical character of young cardiomyopathic hamsters (BI014.6) compared with age-matched healthy hamsters (FIB). In the present study we report following ; (1) The relative weights of the heart and kidney were significantly increased in the cardiomyopathic hamsters compared with the healthy hamsters ; (2) Plasma levels of CPK, GOT, and GPT were significantly higher in the cardiomyopathic hamsters than in the healthy hamsters ; (3) There were no differences in ECG between the cardiomyopathic and healthy hamsters and also arrhythmias at the age of 2.5 months. The intervals of R-R and PQ were significantly shorter in the cardiomyopathic hamsters but the QT interval was significantly longer than in the healthy hamsters. These morphologic aspects and biochemical profiles indicated that the young cardiomyopathic hamsters exhibited a cardiac hypertrophy and disturbance in the heart muscle. However, from the electrophysiological viewpoint, it is probable that the cardiomyopathic hamsters have still managed to be normal at the age.

Journal

  • Advances in Animal Cardiology

    Advances in Animal Cardiology 30(2), 74-81, 1997-12-01

    Japanese Society of Veterinary Cardiology

References:  20

Codes

  • NII Article ID (NAID)
    10008287213
  • NII NACSIS-CAT ID (NCID)
    AN10192925
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    09106537
  • NDL Article ID
    4438069
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-1508
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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