肺水腫におけるニトログリセリン舌下錠の臨床応用  [in Japanese] Chinical Application of the Nitroglycerin Sublingual Tablet to the Plumonary Edema  [in Japanese]

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Author(s)

Abstract

肺水腫は犬の僧帽弁閉鎖不全症の経過中にしばしば遭遇する急性左心不全徴候である。治療には肺うっ血を改善する目的で利尿薬や血管拡張薬が投与される。<BR>今回,ニトログリセリン製剤の中でも即効性の舌下錠を雄では包皮内に,雌には膣内に投与することを考案した。正常犬を用いた実験では,この投与法においても人で舌下投与した場合とほぼ同様の血行動態の変化が得られたことから臨床応用が可能と思われた。<BR>また臨床症状が比較的軽度な肺水腫で来院した症状に初期治療としてニトログリセリン舌下錠の包皮または膣内投与を行ったところ,著明な臨床症状の改善が得られた。

Pulmonary edema is often encountered as an acute symptom of left insufficiency in mitral regurgitation. Diuretics or vasodilator is generally administered to improve pulmonary congestion. Among the nitroglycerin formations, the rapid acting sublingual tablets were selected in this study. A new administration route of sublingual tablets were devised into preputial cavity in male and into vagina in female, Preclinically this administration was performed in clinically healthy dogs. The cardio-vascular behavior after this preclinical administrations to the dogs were almost same of those after sublingual administration to human. We considered that this administration was clinically applicable. Relatively mild cases of pulmonary edema with clinical symptoms, were initially treated with intra-preputial or intra vaginal administration of nitroglycerin sublingual tablets. Remarkable clinical improvement was recognized in these cases.

Journal

  • Advances in Animal Cardiology

    Advances in Animal Cardiology 31(1), 34-42, 1998-06

    Japanese Society of Veterinary Cardiology

References:  6

Codes

  • NII Article ID (NAID)
    10008287443
  • NII NACSIS-CAT ID (NCID)
    AN10192925
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    09106537
  • NDL Article ID
    4585518
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-1508
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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