Volume Expansion Sensitivity of Swelling-Activated Cl^- Channel in Human Epithelial Cells

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Author(s)

Abstract

In human epithelial cell lines, whole-cell swelling-activated Cl<sup>−</sup> current was not directly correlated to cell volume per se, membrane tension or hydrostatic pressure. The current density exhibited a relation described by a Boltzmann function to the square of the cell diameter. Cytochalasin D enhanced the volume sensitivity. These results suggest that the activation mechanism of volume-sensitive Cl<sup>−</sup> channel is related to cytoskeleton-dependent membrane spring energy in human epithelial cells.<br>

Journal

  • The Japanese Journal of Physiology

    The Japanese Journal of Physiology 50(2), 277-280, 2000-04

    THE PHYSIOLOGICAL SOCIETY OF JAPAN

References:  11

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008291213
  • NII NACSIS-CAT ID (NCID)
    AA00691224
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0021521X
  • NDL Article ID
    5413563
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z53-D40
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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