Correlation between Erythropoietin and Lactate in Humans during Altitude Exposure

Access this Article

Author(s)

Abstract

The plasma concentrations of both immunoreactive erythropoietin (EPO) and lactate were determined in four healthy untrained subjects at sea level and on the 2nd or 3rd day at altitudes (1,300 and 3,500 m). The mean plasma EPO (18.8 ± 1.6 mU/ml at sea level) increased significantly on the 3rd day at 1,300 m (25.5 ± 2.0 mU/ml, p < 0.05) and showed an almost three-fold increase on the 2nd day at 3,500 m (53.5 ± 3.7 mU/ml, p < 0.001). Likewise, the mean plasma lactate at 3,500 m (3.98 ± 0.27 mmol/l) was 3.6 times as high as that at sea level (1.11 ± 0.05 mmol/l) (p < 0.001). The plasma EPO concentrations were found to correlate well with the lactate concentrations at sea level and altitudes (r = 0.86, p < 0.01). These results are consistent with the well-known EPO/lactate response to altitudes and suggest that the circulating EPO concentration as well as blood lactate concentration can be used as an index of anaerobic condition.<br>

Journal

  • The Japanese Journal of Physiology

    The Japanese Journal of Physiology 50(2), 285-288, 2000-04

    THE PHYSIOLOGICAL SOCIETY OF JAPAN

References:  15

Codes

  • NII Article ID (NAID)
    10008291229
  • NII NACSIS-CAT ID (NCID)
    AA00691224
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    0021521X
  • NDL Article ID
    5413580
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z53-D40
  • Data Source
    CJP  NDL  J-STAGE 
Page Top