閉ループ条件下における電気刺激を用いた頚動脈洞圧受容器反射伝達特性の同定 Closed-Loop Identification of Carotid Sinus Baroreflex Transfer Characteristics Using Electrical Stimulation

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Author(s)

    • SHISHIDO Toshiaki
    • Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute
    • TATEWAKI Teiji
    • Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute
    • YANAGIYA Yusuke
    • Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute
    • ZHENG Can
    • Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute
    • SUGIMACHI Masaru
    • Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute
    • SUNAGAWA Kenji
    • Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute

Abstract

Although random aortic pressure (AOP) perturbation according to a binary white noise sequence enables us to estimate open-loop dynamic characteristics of the carotid sinus baroreflex under closed-loop conditions, the necessity of arterial catheter implantation limits the applicability of this method in freely moving animal experiments. Thus, we explored a closed-loop system identification method using electrical stimulation. In 6 anesthetized and vagotomized rabbits, we stimulated the aortic depressor nerve with a binary white noise sequence (0-10 Hz) under baroreflex closed-loop conditions while measuring cardiac sympathetic nerve activity (SNA) and AOP. We used a closed-loop identification method to estimate the peripheral arc transfer function from SNA to AOP. The peripheral arc transfer function approximated a second-order low-pass filter and its fitted parameters did not differ from those obtained by an open-loop identification method (dynamic gain: 1.16 ± 0.32 vs. 1.02 ± 0.11; natural frequency: 0.08 ± 0.03 vs. 0.09 ± 0.03 Hz; damping ratio: 1.53 ± 0.15 vs. 1.57 ± 0.21). In 6 different rabbits, we applied intermittent rapid pacing (396 beats/min) under baroreflex closed-loop conditions to estimate the neural arc transfer function from AOP to SNA. The neural arc transfer function approximated a first-order high-pass filter and its fitted parameters did not differ from those obtained by an open-loop identification method (dynamic gain: −1.15 ± 0.45 vs. −1.06 ± 0.05; corner frequency: 0.12 ± 0.05 vs. 0.13 ± 0.03 Hz). In conclusion, the closed-loop identification method using electrical stimulation is effective to estimate the neural and peripheral arc transfer functions.<br>

Journal

  • The Japanese Journal of Physiology

    The Japanese Journal of Physiology 50(3), 371-380, 2000-06

    Physiological Society of Japan

References:  27

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008291639
  • NII NACSIS-CAT ID (NCID)
    AA00691224
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0021521X
  • NDL Article ID
    5525804
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z53-D40
  • Data Source
    CJP  CJPref  NDL  IR  J-STAGE 
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