Effects of Removal of Na〔+〕 and Cl〔-〕 on Spontaneous Electrical Activity, Slow Wave, in the Circular Muscle of the Guinea-Pig Gastric Antrum

• Tomita Tadao

  Institute for Comprehensive Medical Science, Fujita Health University

• Hata Tadayoshi

書誌事項

タイトル別名

• Effects of Removal of Na+ and Cl- on Spontaneous Electrical Activity, Slow Wave, in the Circular Muscle of the Guinea-Pig Gastric Antrum.

抄録

In the circular muscle of the guinea-pig gastric antrum, a decrease in the external Na⁺ to less than 20 mM produced depolarization of the membrane with transient prolongation of the slow wave. This was followed by a high rhythmic activity. The activity was inhibited by reapplication of Na⁺ before recovery. The depolarization in Na⁺-deficient solution was prevented and rhythmic activity continued at about 5/min for at least 6 min by simultaneous removal of K⁺, Ca²⁺, or Cl⁻. After exposure to a Na⁺- and Cl⁻-deficient solution for a few minutes, reapplication of the Na⁺ in Cl⁻-deficient solution inhibited generation of the slow wave until Cl⁻ reapplication. Similar results were obtained when Na⁺ and Cl⁻ were reapplied in the absence of K⁺ after exposure to a Na⁺-, K⁺-free , and Cl⁻-deficient solution, although the inhibition was weaker than Na⁺ reapplication in a Cl⁻-deficient solution. In the presence of furosemide or bumetanide, a strong inhibition of activity was produced by the reapplication of Na⁺ and Cl⁻ after exposure to an Na⁺- and Cl⁻-deficient solution. A hypothesis is presented that intracellular Ca²⁺ concentration ([Ca²⁺]_i) is the most important factor determining the generation and frequency of the slow wave and that [Ca²⁺]_i is regulated by the Na⁺ concentration gradient across the plasma membrane. The recovery of the Na⁺ concentration gradient by Na⁺ reapplication after removal of Na⁺ and Cl⁻ is mainly controlled by a Na⁺-K⁺-Cl⁻ co-transport.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 50 (5), 469-477, 2000

  一般社団法人　日本生理学会

キーワード

• slow wave
• gastric muscle
• Na⁺-K⁺-Cl⁻ co-transport
• furosemide
• bumetanide

詳細情報

• CRID: 1390282680019190144
• NII論文ID: 130004435735
• NII論文ID: 10008291992
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.50.469
• COI: 1:CAS:528:DC%2BD3cXptVaqu7c%3D
• ISSN: 18811396
• ISSN: 0021521X
• ISSN: http://id.crossref.org/issn/0021521X
• NDL書誌ID: 5591196
• PubMed: 11120913
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5591196
• Web Site: https://search.jamas.or.jp/link/ui/2001075124
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可