2,3-Butanedione Monoxime Suppresses Primarily Total Calcium Handling in Canine Heart

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Author(s)

Abstract

Whether 2,3-butanedione monoxime (BDM, ≤5 mmol/l) suppresses primarily crossbridge cycling or total Ca<sup>2+</sup> handling in the blood-perfused whole heart remains controversial. Although BDM seems to suppress primarily total Ca<sup>2+</sup> handling in canine hearts, more evidence is lacking. We therefore analyzed the cardiac mechanoenergetics, namely, E<sub>max</sub> (contractility), PVA (total mechanical energy), and O<sub>2</sub> consumption of canine BDM-treated hearts by our recently developed integrative method to assess myocardial total Ca<sup>2+</sup> handling. This method additionally required the internal Ca<sup>2+</sup> recirculation fraction. We obtained this from the beat constant of the exponential decay component of the postextrasystolic potentiation. Our analysis indicated significant decreases in both internal Ca<sup>2+</sup> recirculation fraction and total Ca<sup>2+</sup> handling in the BDM-treated heart, but virtually no change in the reactivity of E<sub>max</sub> to total Ca<sup>2+</sup> handling. This result corroborates the view that BDM suppresses primarily total Ca<sup>2+</sup> handling rather than crossbridge cycling in the canine blood-perfused heart.<br>

Journal

  • The Japanese Journal of Physiology

    The Japanese Journal of Physiology 50(5), 543-551, 2000-10

    THE PHYSIOLOGICAL SOCIETY OF JAPAN

References:  28

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008292222
  • NII NACSIS-CAT ID (NCID)
    AA00691224
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0021521X
  • NDL Article ID
    5591342
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z53-D40
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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