Ion Channels Permeable to Monovalent and Divalent Cations: A Single-File Two-Site Channel Model.

• Oosawa Yoshio

  International Institute for Advanced Research, Matsushita Electric Industrial Co. Ltd.

抄録

A cation channel from Tetrahymena cilia is permeable to both monovalent and divalent cations. A single-file two-site channel model was introduced for explaining the single channel currents of the channel in mixed solutions of K⁺ and Ca²⁺. In the model it was assumed that two potassium ions or one calcium ion can bind to the binding sites, and that the potassium ions between the binding sites are in a fast equilibrium condition. Single channel currents were calculated from the values of rate constants, ionic concentrations on both sides of the membrane, and the membrane voltages. This model could explain all the observed single channel currents of the channel in K⁺ or Ca²⁺ solution and in mixed solutions of K⁺ and Ca²⁺. The values of the reversal potential in the bi-ionic condition could distinguish this single-file two-site channel model from the single-site channel model or the model in which each ion permeates through the same channel independently (the Goldman-Hodgkin-Katz equation). Experimental data supported this model.<br>

収録刊行物

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 51 (5), 569-576, 2001

  一般社団法人　日本生理学会

キーワード

• nonselective cation channel
• multi-ion channel
• rate theory
• ion permeation
• <i>Tetrahymena</i>

詳細情報

• CRID: 1390001205041813248
• NII論文ID: 130004435790
• NII論文ID: 10008294787
• NII書誌ID: AA00691224
• DOI: 10.2170/jjphysiol.51.569
• COI: 1:CAS:528:DC%2BD38XjvVCitg%3D%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL書誌ID: 6003278
• PubMed: 11734077
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6003278
• Web Site: https://search.jamas.or.jp/link/ui/2002120431
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可