Disappearance of Diurnal Rhythm of Energy Expenditure in Genetically Diabetic Obese Rats.

  • ICHIKAWA Mineko
    Department of Nutrition, Tokyo Metropolitan Institute of Gerontology
  • MIYASAKA Kyoko
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • FUJITA Yoshiaki
    Department of Nutrition, Tokyo Metropolitan Institute of Gerontology
  • SHIMAZOE Takao
    Department of Pharmacology, Faculty of Pharmaceutical Science, Kyushu University
  • FUNAKOSHI Akihiro
    Department of Gastroenterology, National Kyushu Cancer Center

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  • Disappearance of Diurnal Rhythm of Ener

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The daily profile of energy expenditures was examined in the new animal model of genetically diabetic obese rats. The diurnal rhythm was observed at 8 weeks of age, with highest and lowest values for energy consumption per hour observed in the dark and light periods, respectively. However, at 24 weeks of age after the manifestation of noninsulin-dependent diabetes mellitus, the rhythm completely disappeared, but it did not in the control rats.

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