ATP-Sensitive Potassium Channels : Structures, Functions, and Pathophysiology

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Author(s)

Abstract

ATP-sensitive potassium channels (K<SUB>ATP</SUB> channels) play important roles in various tissues by coupling cell metabolic status to electrical activity. Recently, molecular biological and electrophysiological techniques have revealed the molecular basis of the K<SUB>ATP</SUB> channels to be a complex of the Kir6.0 subunit, a member of the inwardly rectifying K<SUP>+</SUP> channel subfamily Kir6.0, and the sulfonylurea receptor (SUR) subunit, a member of ATP-binding cassette (ABC) superfamily; the functional diversity of the various K<SUB>ATP</SUB> channels is being determined by a combination of the Kir6.0 subunit (Kir6.1 or Kir6.2) and the SUR subunit (SUR1 or SUR2) comprising it. Recent studies of the K<SUB>ATP</SUB> channels have suggested mechanisms of K<SUB>ATP</SUB> channel regulation and pathophysiology and also a new model in which ABC proteins regulate the functional expression of ion channels.

Journal

  • The Japanese Journal of Physiology

    The Japanese Journal of Physiology 48(6), 397-412, 1998-12-01

    THE PHYSIOLOGICAL SOCIETY OF JAPAN

References:  161

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Cited by:  2

Codes

  • NII Article ID (NAID)
    10008305518
  • NII NACSIS-CAT ID (NCID)
    AA00691224
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0021521X
  • NDL Article ID
    4652803
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z53-D40
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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