Effect of an Allosteric Modifier of Hemoglobin, RSR-4, on Oxygen Affinity and Oxygen Saturation of Hemoglobin in Rabbits

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Author(s)

Abstract

Theoretically, if the arterial partial oxygen pressure (PaO<SUB>2</SUB>) does not change, a right shift in the oxygen equilibrium curve (OEC) of hemoglobin should reduce arterial oxygen saturation. In this study we investigate whether a right shift in the OEC of hemoglobin decreases transcutaneous oxygen saturation (Tc-SO<SUB>2</SUB>) following the administration of an allosteric effector, 2-[4-(((3, 5-dichloroanilino)-carbonyl) methyl) phenoxy]-2-methylpropionic acid (RSR-4). The effect of RSR-4 on hemoglobin oxygen affinity was studied in four New Zealand white male rabbits. Following intraperitoneal administration of RSR-4, Tc-SO<SUB>2</SUB> decreased in a dose-dependent manner. P<SUB>50</SUB> (partial oxygen pressure at 50% hemoglobin oxygen saturation) in whole blood increased as the concentration of RSR-4 increased. Tc-SO<SUB>2</SUB> decreased as whole-blood affinity (1/P<SUB>50</SUB>) decreased. There was no positive correlation between Tc-SO<SUB>2</SUB> and PaO<SUB>2</SUB>. We concluded that a decrease in hemoglobin oxygen affinity following RSR-4 administration reduced arterial oxygen saturation. This decrease in the presence of an allosteric effector such as RSR-4 in vivo can be detected and monitored as a reduction in Tc-SO<SUB>2</SUB>.

Journal

  • The Japanese Journal of Physiology

    The Japanese Journal of Physiology 48(6), 439-444, 1998-12-01

    THE PHYSIOLOGICAL SOCIETY OF JAPAN

References:  25

Codes

  • NII Article ID (NAID)
    10008305816
  • NII NACSIS-CAT ID (NCID)
    AA00691224
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    0021521X
  • NDL Article ID
    4652864
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z53-D40
  • Data Source
    CJP  NDL  J-STAGE 
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