CBF Change Evoked by Somatosensory Activation Measured by Laser-Doppler Flowmetry: Independent Evaluation of RBC Velocity and RBC Concentration CBF Change Evoked by Somatosensory Activation Measured by Laser-Doppler Flowmetry : Independent Evaluation of RBC Velocity and RBC Concentration

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Author(s)

    • Seki Chie [他] SEKI Chie
    • Akita Laboratory, Japan Science and Technology Corporation, Akita Research Institute of Brain and Blood Vessels
    • KASHIKURA Kenichi
    • Akita Laboratory, Japan Science and Technology Corporation, Akita Research Institute of Brain and Blood Vessels
    • KANNO Iwao
    • Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels

Abstract

The purpose of this study was to examine the timing and magnitude of neuronal activation. We measured the changes in local CBF(LCBF), red blood cell(RBC) velocity and RBC concentration by laser-Doppler flowmetry (LDF) as well as field potential recordings during activation of the somatosensory cortex of the rat in response to alactrical stimulation of the hind paw. Electrical stimuli, 0.1 ms pulses of 1-1.5 mA for 5 s, were applied at 0.2,0.5,5,10 and 50 Hz under α-chloralose anesthesia. LCBF showed the maximum increase at 5 Hz, and rose approximately 0.5 s after the onset of stimulation regardless of the frequency. The maximum freaquency of the filed potentials was also obtained at 5 Hz. During activation of the somatosensory cortex, the onset of rise in RBC concentration did not precede that of RBC velocity, and the peak RBC concentrasion was noted earlier than that both LCBF and RBC velocity, suggesting that both arteriolar diameter and active changes in the capillary contributed to the LCBF response.

Journal

  • The Japanese Journal of Physiology

    The Japanese Journal of Physiology 49(3), 289-296, 1999-06

    THE PHYSIOLOGICAL SOCIETY OF JAPAN

References:  39

Cited by:  12

Codes

  • NII Article ID (NAID)
    10008307230
  • NII NACSIS-CAT ID (NCID)
    AA00691224
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0021521X
  • NDL Article ID
    4867864
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z53-D40
  • Data Source
    CJP  CJPref  NDL  IR  J-STAGE 
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