Teicoplanin投与が有効であった再燃性MRSA骨髄炎の1例

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  • A case of teicoplanin medication in reinfected methicillin-resistant Staphylococcus aureus osteomyelitis.

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A 59-year-old woman with methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis treated using teicoplanin (TEIC) had moderate chronic renal failure, so she was treated carefully with therapeutic drug monitoring (TDM) of TEIC. At first, she was treated with vancomycin (VCM) by intravenous infusion and VCM bead replacement therapy. Short-term remission was achieved, but only 2 months of treatment for renal failure was exacerbated, so the interruption of treatment led her osteomyelitis to recur. TEIC has 2 advantages over other anti-MRSA drugslittle influence on the kidneys, and good treatment of bone-so we chose TEIC for this patient, using TDM to set the adequate dose and interval. TEIC can be used in long-term medication without reducing kidney function and can be used safely and effectively with TDM, meaning TEIC is a possible alternative in treating MRSA osteomyelitis.

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